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Abstract
Chronic kidney disease (CKD) and kidney aging are linked by the accumulation of senescent cells, which may contribute to disease progression.
- Cellular senescence is associated with chronic inflammation and fibrosis in the kidneys.
- The senescence-associated secretory phenotype (SASP) plays a role in the detrimental effects of senescent cells.
- Various senotherapeutic strategies, including senolytics and senomorphics, are explored as potential interventions.
- Artificial intelligence (AI) and machine learning (ML) may enhance the detection and monitoring of senescent cells in both experimental and clinical contexts.
- Understanding the mechanisms of senescence could lead to targeted treatments aimed at slowing CKD progression.
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