Resistance exercise attenuates IKKε phosphorylation and hepatic fat accumulation of obese mice

Resistance exercise training reduced hepatic fat content and improved metabolic markers in obese mice.

• Obese mice on a high-fat diet experienced increased body weight, adiposity, and impaired insulin sensitivity.
• High-fat diet mice showed elevated fasting glucose levels and increased hepatic fat accumulation.
• Increased phosphorylation of IκB kinase (IKK) ɛ and lipogenesis-related proteins were observed in the liver of obese mice.
• Mice that underwent resistance exercise training demonstrated lower body weight and reduced adiposity compared to non-exercised obese mice.
• Resistance exercise was associated with decreased IKKɛ phosphorylation and hepatic fat content in exercised obese mice.
• Overall, resistance exercise training may improve liver fat metabolism and blood sugar regulation in the context of obesity.

AI simplified