Acanthopanax senticosus fruit may improve insulin resistance and liver fat by affecting energy regulation and fat-making genes in obese mice on a high-fat diet

Goka fruit (GF) supplementation led to improved glucose tolerance and insulin sensitivity in high-fat diet-induced obese mice after 12 weeks of treatment.

• GF treatment at doses of 500 and 1000 mg/kg resulted in reduced plasma insulin levels.
• There was a notable decrease in liver lipid accumulation in treated mice.
• GF administration was associated with decreased expression of fatty acid synthase in the liver.
• Cholesterol 7-alpha-hydroxylase expression increased in the liver following GF treatment.
• AMPK phosphorylation in the liver was elevated after administration of Goka fruit.

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