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The fruit of Acanthopanax senticosus (Rupr. et Maxim.) Harms improves insulin resistance and hepatic lipid accumulation by modulation of liver adenosine monophosphate–activated protein kinase activity and lipogenic gene expression in high-fat diet–fed obese mice
Acanthopanax senticosus fruit may improve insulin resistance and liver fat by affecting energy regulation and fat-making genes in obese mice on a high-fat diet
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Abstract
Goka fruit (GF) supplementation led to improved glucose tolerance and insulin sensitivity in high-fat diet-induced obese mice after 12 weeks of treatment.
- GF treatment at doses of 500 and 1000 mg/kg resulted in reduced plasma insulin levels.
- There was a notable decrease in liver lipid accumulation in treated mice.
- GF administration was associated with decreased expression of fatty acid synthase in the liver.
- Cholesterol 7-alpha-hydroxylase expression increased in the liver following GF treatment.
- AMPK phosphorylation in the liver was elevated after administration of Goka fruit.
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