Vernonia cinerea water extract improves insulin resistance in high-fat diet–induced obese mice

Vernonia cinerea water extract significantly reduced hyperglycemia, hyperinsulinemia, hyperleptinemia, and hyperlipidemia in high-fat diet-induced obese mice.

• Treatment with Vernonia cinerea at doses of 250 and 500 mg/kg improved insulin sensitivity in obese mice.
• Obese mice receiving the extract showed increased levels of serum adiponectin and decreased levels of proinflammatory cytokines.
• The treatment led to reduced triglyceride storage in the liver and skeletal muscle.
• Fat cell size was smaller in the groups treated with the extract compared to the high-fat diet group.
• Phosphorylation of key pathways (PI3K and AMPK) was upregulated in liver, skeletal muscle, and adipose tissue of treated mice.
• The glucose transporter 4 was increased in muscle and adipose tissue in the Vernonia cinerea-treated obese mice.

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