The New England journal of medicine

Retatrutide, a drug activating three hormone receptors, for treating obesity

Updated

Abstract

Retatrutide is a triple-receptor agonist of three key hormones related to glucose regulation.

  • It targets glucose-dependent insulinotropic polypeptide, glucagon-like peptide-1, and glucagon receptors.
  • This mechanism suggests potential roles in managing blood sugar levels.
  • The interaction with these receptors may influence metabolic processes.
  • Further investigation is needed to understand its full effects on glucose homeostasis.

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