Retinal patterns and the cellular repertoire of neuropsin (Opn5) retinal ganglion cells

📖 Top 20% JournalNov 7, 2021The Journal of comparative neurology

Patterns and types of light-sensitive retinal nerve cells called neuropsin (Opn5) ganglion cells

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Abstract

is restricted to , showing greater densities in the dorsotemporal quadrant of the retina.

Opn5-RGCs are nonhomogeneously distributed, indicating a specific spatial arrangement within the retina.
The central targets of Opn5-RGCs show a bias towards regions involved in image formation and stabilization.
Molecular and electrical profiling suggest that Opn5-RGCs belong to specific types that are responsive to visual stimuli like edges and motion.
These findings contribute to understanding the roles of atypical opsins in retinal function.

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Obtaining a parts list of the sensory components of the retina is vital to understand the effects of light in behavior, health, and disease. Rods, cones, and intrinsically photosensitive (ipRGCs) are the best described photoreceptors in the mammalian retina, but recent functional roles have been proposed for retinal (Opn5)-an atypical opsin. However, little is known about the pattern of Opn5 expression in the retina. Using cre (Opn5) and cre-dependent reporters, we uncover patterns of Opn5 expression and find that Opn5 is restricted to retinal ganglion cells (RGCs). Opn5-RGCs are nonhomogenously distributed through the retina, with greater densities of cells located in the dorsotemporal quadrant. In addition to the local topology of these cells, using cre-dependent AAV viral tracing, we surveyed their central targets and found that they are biased towards image-forming and image-stabilizing regions. Finally, molecular and electrophysiological profiling reveal that Opn5-RGCs comprise previously defined RGC types that respond optimally to edges and object-motion (F-mini-ONs, HD2, HD1, LEDs, ooDSRGCs, etc.). Together, these data describe the second collection of RGCs that express atypical opsins in the mouse, and expand the roles of image-forming cells in retinal physiology and function. cre

Key numbers

520.8 ± 41.4 cells/mm

Cell Density in

Density of -expressing cells in the ()

5.9 ± 1.1 cells/mm

Cell Density in

Density of -expressing cells in the ()

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Abstract

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