Full text is available at the source.
The REV-ERB Nuclear Receptors: Timekeepers for the Core Clock Period and Metabolism
REV-ERB Proteins as Regulators of the Body’s Internal Clock and Metabolism
AI simplified
Abstract
Deletion of both REV-ERBα and REV-ERBβ in mice reveals their significant role in regulating circadian rhythms.
- REV-ERB nuclear receptors are essential for maintaining the core mammalian molecular clock.
- These receptors are linked to the regulation of metabolism and physiological processes.
- Specific functions of REV-ERBs were identified in various tissues through tissue-specific deletion.
- REV-ERBs help maintain normal physiological functions and may protect against metabolic dysfunction.
AI simplified