REV-ERB Proteins as Regulators of the Body’s Internal Clock and Metabolism

Deletion of both REV-ERBα and REV-ERBβ in mice reveals their significant role in regulating circadian rhythms.

• REV-ERB nuclear receptors are essential for maintaining the core mammalian molecular clock.
• These receptors are linked to the regulation of metabolism and physiological processes.
• Specific functions of REV-ERBs were identified in various tissues through tissue-specific deletion.
• REV-ERBs help maintain normal physiological functions and may protect against metabolic dysfunction.

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