Discrete functions of nuclear receptor Rev-erbα couple metabolism to the clock

Rev-erbα modulates the clock and metabolism through distinct genomic mechanisms.

• Rev-erbα binds directly to the genome to control the circadian clock by competing with activating ROR transcription factors.
• The regulation of metabolic genes by Rev-erbα involves recruiting the HDAC3 co-repressor via cell type-specific transcription factors.
• This competition between Rev-erbα and ROR TFs serves as a universal mechanism for maintaining the molecular clock across various tissues.
• Rev-erbα’s interaction with lineage-determining factors enables a tissue-specific regulation of metabolism, adapting to each tissue's needs.

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