Separate Roles of REV-ERB in Body Clock and Other Gene Regulation

The molecular clock regulates various cellular processes related to growth and metabolism.

• Rev-erba functions as an internal feedback inhibitor of the core molecular clock.
• This feedback inhibition may influence the activity of the circadian clock.
• Rev-erba is also involved in regulating metabolic processes specific to different tissues.
• The findings suggest a complex interplay between the molecular clock and metabolic homeostasis.

Simplified