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Segregation of Clock and Non-Clock Regulatory Functions of REV-ERB
Separate Roles of REV-ERB in Body Clock and Other Gene Regulation
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Abstract
The molecular clock regulates various cellular processes related to growth and metabolism.
- Rev-erba functions as an internal feedback inhibitor of the core molecular clock.
- This feedback inhibition may influence the activity of the circadian clock.
- Rev-erba is also involved in regulating metabolic processes specific to different tissues.
- The findings suggest a complex interplay between the molecular clock and metabolic homeostasis.
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