How Spsb1 and Spsb4 Control the Breakdown of RevErbα and Influence the Body’s Daily Clock

Spsb4 is identified as a potential novel E3 ligase that may regulate RevErbα stability.

• Circadian clock proteins are essential for daily rhythms in gene expression and physiology.
• The ubiquitin proteasome system is crucial for controlling the stability of core clock components.
• Spsb1 and Spsb4 facilitate the process of tagging RevErbα for degradation.
• Spsb2 and Spsb3 do not interact with RevErbα or influence its stability.
• The interaction of Spsb paralogs with RevErbα is associated with regulation of circadian clock periodicity.

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