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The E3 Ligases Spsb1 and Spsb4 Regulate RevErbα Degradation and Circadian Period
How Spsb1 and Spsb4 Control the Breakdown of RevErbα and Influence the Body’s Daily Clock
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Abstract
Spsb4 is identified as a potential novel E3 ligase that may regulate RevErbα stability.
- Circadian clock proteins are essential for daily rhythms in gene expression and physiology.
- The ubiquitin proteasome system is crucial for controlling the stability of core clock components.
- Spsb1 and Spsb4 facilitate the process of tagging RevErbα for degradation.
- Spsb2 and Spsb3 do not interact with RevErbα or influence its stability.
- The interaction of Spsb paralogs with RevErbα is associated with regulation of circadian clock periodicity.
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