Full text is available at the source.
Daily rhythms of REV-ERBα and its role as transcriptional repressor of clock genes in fish hepatic oscillator
Daily cycles of REV-ERBα and its role in turning off clock genes in the fish liver's internal clock
AI simplified
Abstract
A 12-hour shift in feeding time induced a parallel shift in the hepatic rhythm of rev-erbα expression in goldfish.
- REV-ERBα is food-entrainable in the goldfish liver.
- Light primarily drives rev-erbα rhythmic expression in the hypothalamus.
- Activation of REV-ERBα led to a slight decrease in locomotor activity before light onset and food arrival.
- REV-ERBα activation downregulated hepatic expression of key clock genes, including bmal1a and clock1a.
- The repressive effect of REV-ERBα on hepatic clock gene expression was confirmed in vitro using specific agonists and antagonists.
AI simplified