Role of lateral septum glucagon-like peptide 1 receptors in food intake

Intra-LS administration of Exendin 4 (Ex4) suppressed overnight chow and high-fat diet intake in rats.

• GLP-1 receptor binding was demonstrated throughout the rat lateral septum (LS) using a fluorescently labeled agonist.
• The GLP-1 receptor antagonist Exendin (9-39) (Ex9) increased food intake relative to vehicle controls.
• Intra-LS Ex9 significantly increased consumption of 0.25 M sucrose and 4% corn oil during 2-hour tests.
• Intra-LS administration of Ex4 did not induce pica or affect anxiety-like behavior in the elevated plus maze.
• Blockade of GLP-1R in the intermediate subdivision of the LS did not influence motivation for sucrose, despite a nutrient preload suppressing operant responding.
• In contrast, blocking GLP-1R in the dorsal subdivision of the LS increased both motivation for sucrose and overnight chow intake.

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