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Abstract
718 cases of ovarian cancer were confirmed over 2,974,672 person-years of follow-up.
- Rotating night shift work did not show an association with ovarian cancer risk in either the Nurses' Health Study or NHSII.
- For women with 15 to 19 years of night shift work, the hazard ratio was 1.28, indicating a potential increase in risk, though not statistically significant.
- For those working 20 or more years of rotating night shifts, the hazard ratio was 0.80, suggesting a potential decrease in risk, but this also lacked statistical significance.
- The findings indicate no clear link between the duration of rotating night shift work and ovarian cancer risk.
- Further investigation into the role of melatonin in relation to ovarian cancer risk may be beneficial.
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