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Ruminal microbial dysbiosis induces mastitis in dairy goats by activating oxidative stress and ferritinophagy-ferroptosis
Imbalance of stomach microbes may cause udder inflammation in dairy goats by triggering cell stress and iron-related cell death
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Abstract
A high-concentration diet resulted in a milk somatic cell count exceeding 500,000/mL, indicating mastitis in dairy goats.
- Subacute ruminal acidosis (SARA) was observed with prolonged ruminal pH levels below 5.8 in goats fed a high-concentration diet.
- Disruption of ruminal microbiota and elevated serum levels of LPS, TNF-α, and IL-1β were associated with the high-concentration diet.
- Ruminal microbiota transplantation from affected goats induced mastitis in mice, linked to oxidative stress and a specific cell death process.
- The compound ferrostatin-1 alleviated mastitis symptoms in mice, suggesting a potential therapeutic approach.
- LPS exposure triggered oxidative stress and a specific cell death process in mouse mammary epithelial cells in a dose-dependent manner.
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