Subacute ruminal acidosis induces hepatic injury in dairy goats via oxidative stress and ferritinophagy-ferroptosis axis

High-concentrate diets in dairy goats are associated with elevated liver inflammation and significant oxidative stress changes.

• Prolonged high-concentrate feeding can lead to subacute rumen acidosis (SARA), resulting in a drop in ruminal pH.
• Damaged rumen barriers allow large amounts of lipopolysaccharide (LPS) to enter the bloodstream and accumulate in the liver.
• LPS is linked to liver injury in mice, potentially through the activation of a specific cell death pathway called ferroptosis.
• Transplantation of disrupted rumen microbiota from dairy goats into mice induces liver injury via the activation of the ferritinophagy-ferroptosis axis.
• In vitro stimulation with LPS increases oxidative stress and inflammation levels in liver cells, suggesting a harmful effect of the disturbed rumen microbiota.

AI simplified