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Aging and Diet Restriction Uniquely Affect Sarcosine Levels in Rodents and Humans
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Abstract
Dietary restriction (DR) significantly modulates the rat metabolome, surpassing the effects of aging.
- Circulating sarcosine levels are reduced with aging but increased by DR.
- Ames dwarf mice, known for their longevity, exhibit elevated sarcosine levels.
- Sarcosine acts as a key component in the metabolome network of aged rats.
- In cultured cells, sarcosine can activate autophagy and enhances autophagic processes in living organisms.
- These findings suggest that sarcosine may serve as a biomarker for aging and dietary restriction in mammals.
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