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Mutual, reciprocal SDF-1/CXCR4 interactions between hematopoietic and bone marrow stromal cells regulate human stem cell migration and development in NOD/SCID chimeric mice
Two-way SDF-1 and CXCR4 signaling between blood-forming and bone marrow support cells controls human stem cell movement and growth in mice
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Abstract
The chemokine SDF-1 and its receptor CXCR4 are critical for the regulation of multiple cell types, including hematopoietic and stromal stem cells.
- CXCR4 is expressed by both hematopoietic and stromal cells, with stromal cells being the primary source of SDF-1 in the bone marrow.
- Stress-induced changes in SDF-1 and CXCR4 levels may facilitate the recruitment of immature and maturing leukocytes from the bone marrow to damaged tissues.
- SDF-1 trafficking is mediated by CXCR4 on endothelial and various stromal cells, but not on hematopoietic cells.
- Transcytosis of functional SDF-1 occurs in regions rich in stem cells, influencing interactions within the stem cell niche.
- Dynamic expression levels of SDF-1 and CXCR4 are associated with the proliferation of progenitor cells and the mobilization of leukocytes.
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