G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4

Jun 18, 2002Nature immunology

G-CSF helps move stem cells by lowering bone marrow signals and increasing stem cell receptors

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Abstract

G-CSF treatment resulted in a decrease of SDF-1 and an increase in CXCR4 in the bone marrow.

  • G-CSF induced a reduction of the chemokine SDF-1 in the bone marrow while increasing its receptor CXCR4.
  • The decrease in bone marrow SDF-1 correlated with the mobilization of stem cells, primarily due to degradation by neutrophil elastase.
  • Inhibition of elastase reduced both the degradation of SDF-1 and stem cell mobilization.
  • Neutralizing antibodies against CXCR4 or SDF-1 inhibited stem cell mobilization in both human and mouse models.
  • SDF-1 CXCR4 signaling is associated with the egress of stem cells from the bone marrow to the blood.

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