Mobilization of Myeloma Cells Involves SDF‐1/CXCR4 Signaling and Downregulation of VLA‐4

Dec 23, 2003Stem cells (Dayton, Ohio)

Movement of myeloma cells involves SDF-1/CXCR4 signals and reduced VLA-4 levels

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Abstract

A statistically significant decrease in the levels of SDF-1 and surface expression of CXCR4 on myeloma cells was observed during apheresis collections in 12 multiple myeloma patients.

  • Homing of hematopoietic stem cells is associated with active signaling through SDF-1/CXCR4 and upregulation of adhesion molecules.
  • Mobilization of hematopoietic stem cells requires downregulation of adhesion molecules and disruption of SDF-1/CXCR4 signaling.
  • Surface expression of VLA-4 on myeloma cells decreased significantly during apheresis collections compared to premobilization bone marrow samples.
  • Myeloma cells from apheresis collections exhibited decreased adhesion and migration in response to SDF-1.
  • Short incubation with interleukin-6 may reverse the decreased migration of myeloma cells towards SDF-1.

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