[The role of stromal cell-derived factor and its receptor-CXCR4 in G-CSF-induced hematopoietic stem cell mobilization].

Jul 27, 2007Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi

How a signaling protein and its receptor help blood stem cells move in response to a growth factor

AI simplified

Circadian BiologyCircadian Biology on OpenScience ↗PubMed ↗

Abstract

SDF-1 concentration in mobilized bone marrow was 7.23 +/- 0.66 microg/L after G-CSF treatment.

  • SDF-1 levels decreased in bone marrow after a 5-day G-CSF injection, and the concentration gradient between bone marrow and peripheral blood disappeared.
  • CXCR4 expression increased on mobilized CD34 cells compared to steady state bone marrow, with rates of 65.80 +/- 24.68% in mobilized bone marrow and 27.54 +/- 26.03% in mobilized peripheral blood.
  • CXCR4 expression on mobilized peripheral blood CD34+ cells was significantly lower than that in steady state and mobilized bone marrow (P < 0.05).
  • Blocking SDF-1 signaling with monoclonal antibodies significantly reduced G-CSF-induced mobilization in mice, resulting in decreased white blood cell counts and progenitor cells in circulation.

AI simplified

Related papers

Feb '07
The role of matrix metalloproteinase-9 in stem cell release triggered by granulocyte colony-stimulating factor
research support, non-u.s. gov't
Aug '08
Breakdown of bone marrow signals by MMP-9 and its role in stem cell release triggered by G-CSF
top 10% journal
cited by 57 papers
research support, non-u.s. gov't
Jun '02
G-CSF helps move stem cells by lowering bone marrow signals and increasing stem cell receptors
cited by 1,080 papers
research support, non-u.s. gov't
Feb '05
The CXCR4-activating peptide CTCE-0021 quickly increases certain immune cells in the blood and works together with a growth factor to boost this effect
cited by 71 papers
research support, u.s. gov't, p.h.s.
Feb '08
Bone marrow cells produce carboxypeptidase M that trims stromal cell factor-1alpha, possibly affecting stem cell movement
top 20% journal
cited by 54 papers
research support, non-u.s. gov't
Jan '04
Lack of GRK6 protein increases neutrophil movement toward CXCR4 signals in the lab but reduces their response to G-CSF in living organisms
cited by 71 papers
journal article
Oct '03
Bone marrow contains CXCR4-positive stem cells with early muscle, liver, and nerve cell traits
cited by 252 papers
comparative study
Jul '06
Two-way SDF-1 and CXCR4 signaling between blood-forming and bone marrow support cells controls human stem cell movement and growth in mice
cited by 299 papers
journal article
Jan '07
Human galectin-1 may reduce inflammation by blocking the movement of blood-forming stem cells
cited by 20 papers
research support, non-u.s. gov't

what lands in your inbox each week:

  • 📚7 fresh studies
  • 📝plain-language summaries
  • ✅direct links to original studies
  • 🏅top journal indicators
  • 📅weekly delivery
  • 🧘‍♂️always free

Recent issues from the circadian biology brief

issue #35
Bacteria exposure resets your internal clock independently of immune responses
2 days ago7 studies
issue #34
Night owl teens got 47 minutes more sleep with bright light glasses
1 week ago7 studies
issue #33
Working out at your optimal time cuts blood pressure twice as much
2 weeks ago7 studies
issue #32
Bright light preference disrupts mouse sleep patterns even without human lifestyle factors
3 weeks ago7 studies
issue #31
Artificial light at night disrupts bird sleep and metabolism across 675 studies
4 weeks ago7 studies
issue #30
Your hair can reveal your circadian rhythm from a single sample
5 weeks ago7 studies
issue #29
Your body clock needs 25% more epidural painkiller at night
6 weeks ago7 studies
issue #28
Night owls have 123% higher mortality risk after age 81
7 weeks ago7 studies
issue #27
Light pollution linked to 31% higher diabetes risk in major analysis
8 weeks ago7 studies
issue #26
Wearables can detect early dementia signs with 70-95% accuracy across 200,000+ people
9 weeks ago7 studies
explore the archive
See more issues from the circadian biology brief