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Degradation of BM SDF-1 by MMP-9: the role in G-CSF-induced hematopoietic stem/progenitor cell mobilization
Breakdown of bone marrow signals by MMP-9 and its role in stem cell release triggered by G-CSF
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Abstract
The concentration of SDF-1 in healthy donors' bone marrow plasma decreased significantly after 5 days of G-CSF administration.
- SDF-1 levels remained unchanged in peripheral blood despite the decrease in bone marrow plasma.
- Mobilized bone marrow plasma showed reduced ability to attract CD34(+) cells compared to steady-state bone marrow plasma.
- Increased levels of MMP-9 protein and mRNA in bone marrow plasma correlated with the decrease in SDF-1.
- MMP-9 was found to degrade SDF-1, and its activity was stimulated by SDF-1 itself in CD34(+) cells.
- Inhibition of SDF-1 or MMP activity significantly reduced hematopoietic stem/progenitor cell mobilization in mice.
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