The Journal of clinical investigation

Breaking the CXCR4/CXCL12 signaling during blood stem cell release caused by GCSF or cyclophosphamide

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Mobilization of hematopoietic progenitor cells (HPCs) by GCSF is associated with the cleavage of the CXCR4 receptor on these cells.

  • Cleavage of CXCR4 on HPCs leads to a loss of their ability to respond to the chemokine SDF-1.
  • Concentrations of SDF-1 in the bone marrow decrease during the mobilization of HPCs.
  • This decrease in SDF-1 coincides with the accumulation of serine proteases that can cleave and inactivate SDF-1.
  • Both SDF-1 and CXCR4 are crucial for the retention of HPCs in the bone marrow.
  • The degradation of SDF-1 and CXCR4 may be a key factor in the process of HPC mobilization into peripheral blood.

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