Association of Self-Reported Sleep and Circadian Measures With Glycemia in Adults With Prediabetes or Recently Diagnosed Untreated Type 2 Diabetes

May 4, 2019Diabetes care

Links Between Sleep and Body Clock Patterns and Blood Sugar in Adults with Prediabetes or New Untreated Type 2 Diabetes

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Abstract

The cohort of 962 adults with prediabetes or untreated type 2 diabetes reported a mean sleep duration of 6.6 ± 1.3 hours.

Poor sleep quality was reported by 54% of participants, and 64% were at high risk for obstructive sleep apnea.
Higher levels of hemoglobin A1c were significantly related to individuals reporting less than 5 hours or more than 8 hours of sleep per night.
Sleep duration of more than 8 hours was associated with higher fasting glucose levels, while less than 6 hours was linked to increased body mass index (BMI).
Shift work was associated with higher BMI.
Social jet lag and a delayed sleep pattern were linked to elevated blood pressure.

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OBJECTIVE: Sleep disturbances and circadian misalignment (social jet lag, late chronotype, or shift work) have been associated with worse glycemic control in type 2 diabetes (T2D). Whether these findings apply to adults with prediabetes is yet unexplored. We hypothesized that self-reported short sleep, poor sleep quality, and/or circadian misalignment are associated with higher glycemia, BMI, and blood pressure (BP) in adults with prediabetes or recently diagnosed, untreated T2D.

RESEARCH DESIGN AND METHODS: Our cohort included 962 overweight/obese adults ages 20-65 years with prediabetes or recently diagnosed, untreated T2D who completed a 2-h oral glucose tolerance test and validated sleep questionnaires. Independent associations of sleep and circadian variables with glycemia, BMI, and BP were evaluated with regression models.

RESULTS: The multiethnic cohort was 55% men, with mean ± SD age 52.2 ± 9.5 years and BMI 34.7 ± 5.5 kg/m. Mean sleep duration was 6.6 ± 1.3 h. Poor sleep quality was reported by 54% and high risk for obstructive sleep apnea by 64%. HbAwas significantly higher in those reporting <5 or >8 h sleep per night. Sleep duration >8 h was also associated with higher fasting glucose and <6 h with higher BMI. Shift work was also associated with higher BMI. Social jet lag and delayed chronotype were associated with higher BP. 2 1c

CONCLUSIONS: In our cohort, self-reported short and long sleep were both associated with adverse measures of glycemia, and short sleep and shift work were associated with higher BMI. Further research using objective measures of sleep is needed to better delineate the relationship between sleep and glycemia in adults with prediabetes or T2D.

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Association of Self-Reported Sleep and Circadian Measures With Glycemia in Adults With Prediabetes or Recently Diagnosed Untreated Type 2 Diabetes

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