BMJ open

Semaglutide as an additional treatment for obesity in teens taking antipsychotic drugs: plan for a first feasibility study

Updated

Abstract

The aim of this trial is to assess the feasibility of a 36-week treatment period with a glucagon-like peptide-1 receptor agonist in adolescents with antipsychotic-associated obesity.

  • Adolescents treated with antipsychotic medication are at increased risk for obesity and metabolic complications.
  • Glucagon-like peptide-1 receptor agonists have shown effectiveness in treating obesity in both adults and adolescents.
  • The study will evaluate treatment completion from baseline to the end of a 36-week period.
  • Results could inform the design of a larger randomized controlled trial.

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