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Beyond fat: Does semaglutide affect lean mass?
Does semaglutide change muscle and other lean body mass as well as fat?
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Abstract
Semaglutide treatment is associated with both decreases in lean mass and increases in the ratio of lean mass to total body mass.
- Significant weight loss occurs with semaglutide, but its effects on lean mass are debated.
- Some studies indicate that weight loss from semaglutide leads to reductions in both lean and fat mass.
- In contrast, larger clinical trials report significant decreases in lean mass during semaglutide treatment.
- The conflicting results highlight the need for further research on semaglutide's impact on body composition.
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