Does semaglutide change muscle and other lean body mass as well as fat?

Semaglutide treatment is associated with both decreases in lean mass and increases in the ratio of lean mass to total body mass.

• Significant weight loss occurs with semaglutide, but its effects on lean mass are debated.
• Some studies indicate that weight loss from semaglutide leads to reductions in both lean and fat mass.
• In contrast, larger clinical trials report significant decreases in lean mass during semaglutide treatment.
• The conflicting results highlight the need for further research on semaglutide's impact on body composition.

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