JAMA cardiology

Semaglutide’s effectiveness and safety in people with different levels of frailty

Updated

Abstract

The influence of frailty on the benefit-risk balance of glucagon-like peptide-1 receptor agonists (GLP-1 RA) is uncertain.

  • Frailty may affect how patients respond to GLP-1 RA treatment.
  • The benefit-risk balance of GLP-1 RAs is not clearly established in frail individuals.
  • Further investigation is needed to understand the implications of frailty in this context.

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