Targeting the senescence-associated secretory phenotype to modify osteoarthritis in aging

Osteoarthritis (OA) is correlated with aging and features the gradual degradation of cartilage.

• The senescence-associated secretory phenotype (SASP) of chondrocytes may play a crucial role in OA pathology through the continuous release of inflammatory factors.
• Molecular processes leading to chondrocyte aging include signaling pathways, oxidative stress, mitochondrial dysfunction, and epigenetic changes.
• Senotherapeutic strategies could target SASP to reduce inflammation while preserving cartilage health.
• Nanotechnology and extracellular vesicle therapies may aid in rejuvenating aging chondrocytes.
• Identifying early indicators of OA could help delay its onset and maintain joint health as individuals age.

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