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Abstract
Out of 283 screened articles, 87 were included, revealing a link between inflammaging and increased vulnerability to periodontal disease in older adults.
- Aging is associated with chronic low-grade inflammation and a decline in immune function.
- Cellular senescence contributes to the release of pro-inflammatory factors, impacting tissue health.
- Inflammaging may alter host responses, leading to impaired healing and increased tissue destruction in periodontal diseases.
- Increased markers of senescence and dysregulated immune responses are linked to greater periodontal tissue loss.
- Systemic diseases like Alzheimer's, diabetes, and cardiovascular disease may exacerbate inflammation in periodontal conditions.
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