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Abstract
Senescent cells in the brain display significant heterogeneity and are influenced by environmental factors.
- Senescent cells arise from various brain cell types and exhibit diverse molecular profiles.
- The process of senescence is dynamic, shaped by changing environmental conditions.
- Differences in how senescence is triggered and maintained vary among cell types and brain regions.
- Recent advances in technologies like single-cell transcriptomics enhance the understanding of senescent cells.
- Integrating multimodal molecular profiling with functional studies in mice may improve insights into senescence in brain aging and disease.
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