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Abstract
Senescent cells (SnCs) are confirmed as a core biological mechanism driving multiple aging-related diseases.
- The formation of SnCs and their roles in tissue damage are systematically reviewed.
- Senolytics may induce programmed cell death in SnCs by targeting their anti-apoptotic pathways.
- Immuno-senolytics may utilize immune mechanisms such as vaccines and engineered cell therapies to eliminate SnCs.
- Senomorphics could modify the secretory profile of SnCs by targeting specific signaling pathways or epigenetic changes.
- Challenges for clinical application include SnC heterogeneity, lack of specific markers, and potential off-target effects.
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