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Abstract
Cellular senescence can be classified into distinct categories termed 'senotypes' based on various factors.
- Senescence is influenced by cell type, species, inducing stress, tissue environment, and time.
- The proposed framework for senotypes includes cell identity, inducing mechanisms, temporal stages, molecular features, and functional effects.
- Senotypes can help interpret incomplete data from tissue-derived senescent cells.
- Classification should be based on combinations of core characteristics rather than individual markers.
- Advancements in technologies allow for detailed characterization of senotypes, which may enhance the development of targeted therapies.
Simplified
Longevity & Aging