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Expression of serotonin receptor HTR4 in glucagon-like peptide-1-positive enteroendocrine cells of the murine intestine
Serotonin receptor HTR4 found in gut cells that produce glucagon-like peptide-1 in mice
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Abstract
HTR2A, HTR2B, and HTR4 are found in individual solitary cells in the murine intestinal epithelium.
- Serotonin is synthesized in enterochromaffin cells and interacts with various 5-HT receptors in the gastrointestinal tract.
- HTR2A, HTR2B, and HTR4 colocalize with serotonin in the intestinal epithelium, while HTR2C is located in the lamina propria.
- In murine intestinal organoids, the colocalization of HTR2A and HTR4 with serotonin mirrors in vivo patterns.
- Tegaserod, an HTR4 agonist, does not change plasma GLP-1 levels when administered intraperitoneally or intragastrically in fasted mice.
- Intragastric administration of tegaserod reduces plasma GLP-1 levels induced by dietary lipids, an effect blocked by the HTR4 antagonist RS39604.
- These findings indicate that enteroendocrine cells in the ileum express HTR4 and suggest potential paracrine interactions between enterochromaffin and enteroendocrine cells.
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