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Abstract
Polygala tenuifolia polysaccharide (PTP) significantly improved the disruption of metabolites and gut microbiota associated with Alzheimer's disease.
- Nineteen metabolites, including leukotriene B4 and vanylglycol, were significantly reduced with PTP treatment, while two metabolites were elevated.
- PTP treatment was significantly enriched in metabolic pathways related to Sphingolipid, Glycerophospholipid, Tyrosine, and Arachidonic acid metabolism.
- Analysis of gut bacteria showed that PTP treatment significantly increased the relative abundance of Alistipes and specific Lachnospiraceae groups.
- Significant changes in gut microbiota were closely associated with the observed differences in endogenous metabolites.
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