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Serum metabolomics combined with gut microbiota reveals the effects of Polygala tenuifolia polysaccharide on the metabolic and microbial profiles in SAMP8 mouse
Polygala tenuifolia polysaccharide changes metabolism and gut bacteria in aging mice
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Abstract
Polygala tenuifolia polysaccharide (PTP) significantly improved the disruption of metabolites and gut microbiota associated with Alzheimer's disease.
- Nineteen metabolites, including leukotriene B4 and vanylglycol, were significantly reduced with PTP treatment, while two metabolites were elevated.
- PTP treatment was significantly enriched in metabolic pathways related to Sphingolipid, Glycerophospholipid, Tyrosine, and Arachidonic acid metabolism.
- Analysis of gut bacteria showed that PTP treatment significantly increased the relative abundance of Alistipes and specific Lachnospiraceae groups.
- Significant changes in gut microbiota were closely associated with the observed differences in endogenous metabolites.
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