Obesity surgeryMar 18, 2016

How Sex Affects Weight and Metabolism After Weight-Loss Surgery in Obese Patients with Sleep Apnea and Type 2 Diabetes

GLP-1 Therapies Weekly Brief ↗PubMed ↗DOI ↗

Updated Apr 5, 2026

Abstract

Significant improvements in sleep parameters, obesity indices, and metabolic outcomes were observed in 35 patients who underwent Roux-en-Y gastric bypass surgery.

Both men and women with obstructive sleep apnea (OSA) showed notable enhancements in sleep quality and obesity metrics after surgery.
Men exhibited higher baseline triglyceride levels and lower high-density lipoprotein (HDL) levels compared to women.
At follow-up, men had a larger neck circumference than women.
Only triglyceride levels in men improved more significantly than in women after the surgery.
The improvements in sleep and obesity measures were associated with metabolic outcomes for both sexes.

Simplified

BACKGROUND: Roux-en-Y gastric bypass (RYGB) surgery is an effective therapy for obstructive sleep apnea (OSA). However, little attention has been paid to the treatment goals systematically stratified by sex. The objective of this study was to assess how sex differences affect obesity indices and metabolic outcomes after RYGB surgery.

METHODS: A sleep questionnaire was conducted and medical histories were taken. Full-night polysomnography (PSG), anthropometric variables, and blood samples were collected.

RESULTS: Thirty-five consecutive patients with OSA who underwent laparoscopic RYGB surgery were prospectively examined for at least 6 months were included in the study. Significant improvements (p < 0.01) in sleep parameters (except for micro-arousal), obesity indices, and metabolic outcomes [except low-density lipoprotein in men and high-density lipoprotein (HDL) in women] were obtained in men and women with OSA. Men had higher baseline triglyceride (TG) (p < 0.01) and lower HDL levels (p < 0.01) but a larger neck circumference (NC) (p = 0.03) at follow-up than did women. However, only TG in men improved more than in women (p = 0.02).

CONCLUSIONS: Sleep parameters, obesity indices, and metabolic outcomes after RYGB surgery were of similar magnitude in women and men with OSA. Alleviating sleep and obesity problems was correlated with metabolic outcomes in men and women.

Full Text

Full text is available at the source.

View Full Text ↗

How Sex Affects Weight and Metabolism After Weight-Loss Surgery in Obese Patients with Sleep Apnea and Type 2 Diabetes

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the glp-1 therapies brief

Abstract

Full Text

Related papers

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the glp-1 therapies brief