Frontiers in endocrinology

Added benefits of SGLT2 inhibitors, GLP-1 receptor agonists, and pioglitazone for type 2 diabetes and fatty liver disease in Asian populations

Updated

Abstract

The study evaluated the effects of adding sodium-glucose cotransporter 2 (SGLT2) inhibitors, glucagon-like peptide-1 receptor agonists (GLP-1RAs), or pioglitazone in Asian adults with type 2 diabetes and metabolic liver disease.

  • SGLT2 inhibitors, GLP-1RAs, and pioglitazone may have distinct impacts on liver health and metabolism in patients with type 2 diabetes.
  • The evaluation focused on adults diagnosed with metabolic dysfunction-associated steatotic liver disease (MASLD).
  • Incremental effects of these medications were assessed alongside existing glucose-lowering treatments.
  • Findings may contribute to understanding optimal treatment combinations for managing diabetes-related liver complications.

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