Effectiveness of diabetes drugs and aerobic exercise for moderate-to-severe sleep apnea in overweight or obese patients

This network meta-analysis compares the effects of SGLT2 inhibitors, GLP-1 receptor agonists, and aerobic exercise on obstructive sleep apnea severity in overweight or obese patients.

• Obstructive sleep apnea is closely associated with obesity and increases the risk of cardiovascular and metabolic diseases.
• SGLT2 inhibitors and GLP-1 receptor agonists may improve obstructive sleep apnea through distinct metabolic mechanisms.
• Aerobic exercise has also shown potential benefits for obstructive sleep apnea severity.
• Direct comparative evidence regarding the efficacy of these three interventions is currently limited.

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