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Custom-designed lipid nanoparticles with siloxane improve cell processing for targeted mRNA therapy delivery
Updated
Abstract
Siloxane-based ionizable lipids improve mRNA delivery efficacy in mice, enabling targeted gene editing and recovery from lung damage.
- Siloxane moieties enhance the cellular uptake of mRNA lipid nanoparticles (LNPs) and their ability to escape endosomes.
- Organ-specific siloxane-incorporated LNPs (SiLNPs) facilitate effective gene knockout in the liver and lungs of various mouse models.
- Lung-targeted Si-N14 LNPs promote recovery from damage caused by viral infections in the lungs.
- The findings suggest potential applications of SiLNPs in mRNA therapeutics for tissue-specific treatments.
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