What this is
- This research compares the effectiveness of two surgical options—single anastomosis duodenoileal bypass (SADI-S) and Roux-en-Y gastric bypass (RYGB)—for patients who underwent sleeve gastrectomy (SG) but experienced inadequate weight loss or complications.
- The study includes data from 141 patients who had revisional surgery between 2007 and 2017, with follow-up extending up to 5 years.
- Key outcomes assessed include percentage total weight loss, quality of life, complications, and micronutrient deficiencies.
Essence
- SADI-S leads to significantly greater weight loss compared to RYGB after failed SG, with no differences in quality of life or complication rates. RYGB is effective for resolving GERD symptoms.
Key takeaways
- SADI-S resulted in greater percentage total weight loss at 1, 2, 3, and 4 years post-surgery compared to RYGB, with values of 22%, 24%, 22%, and 18% for SADI-S vs. 10%, 9%, 7%, and 8% for RYGB, respectively.
- Quality of life scores did not differ significantly between SADI-S and RYGB patients over time, indicating similar post-operative satisfaction despite differences in weight loss.
- Complication rates and micronutrient deficiencies were similar for both surgical options, suggesting that SADI-S does not carry higher risks compared to RYGB.
Caveats
- The study's retrospective design may introduce biases and limit the reliability of the findings. Additionally, the small sample size for long-term follow-up (5 years) may affect the robustness of the conclusions.
- Data on quality of life was incomplete, as not all centers used the same assessment tool, which complicates direct comparisons.
AI simplified
Introduction
The sleeve gastrectomy (SG) is the most frequently performed bariatric procedure to treat (morbid) obesity, accounting for 55.4% of all bariatric procedures worldwide according to the latest IFSO global registry report of 2018 [1]. This comes as no surprise as the SG is a relatively easy to perform surgical procedure when for example compared to the Roux-en-Y gastric bypass (RYGB), with nearly as good results for weight loss and slightly lower complication rates [2]. Despite of its positive results in the first years following surgery, long-term data show revisional surgery rates of up to 22.6% [3–5]. The two main reasons for revisional surgery after SG are insufficient weight loss and gastro-esophageal reflux disease (GERD), of which the first one is most common.
Although many surgical options are available for patients who require revisional surgery after SG, the optimal procedure remains elusive. In cases where GERD is the main complaint and additional weight loss is not the primary goal, it is generally advised to perform a RYGB as this has proven to be the most effective treatment for the resolution of GERD symptoms [6–8]. This effect can be explained by surgical “removal” of the pylorus from the equation, resulting in a lower pressure system and thereby promoting gastric (pouch) emptying. When insufficient weight loss is the main reason to choose for revisional surgery, adding additional restriction can be achieved with a revisional sleeve gastrectomy (Re-SG). One might also look at more malabsorptive procedures. These include the RYGB, one anastomosis gastric bypass (OAGB), and single anastomosis duodenoileal bypass (SADI-S). However, it can only be speculated which surgical option is best. Besides, there is no “one fits all” approach when it comes to revisional surgery. In choosing the most suitable surgical option, it is always the goal to create an optimal equilibrium between weight loss, complications, and micronutrient deficiencies, as well as taking quality of life after surgery into account [9, 10].
As there is little data published on the outcomes of revisional surgery after the SG, often with small sample sizes, there is a large need for data with larger sample sizes and longer follow-up periods. Previously, the short-term outcomes (0–2 years) of the RYGB and SADI-S after SG in the similar set of patients have been reported [11]. We found that SADI-S after SG led to significantly more weight loss, while complication rates and micronutrient deficiencies were similar for SADI-S and RYGB. The aim of the current study is to provide medium-term results of the SADI-S versus RYGB as revisional surgery after the SG by comparing weight loss and other health outcomes (quality of life (QOL), micronutrient deficiencies, and complications) for all patients with 3 to 5 years of follow-up.
Methods
Study Cohort and Data Collection
All patients who underwent revisional bariatric surgery for SADI-S or RYGB after SG from 2007 to 2017 were included in this study. The participating hospitals included Center 1: Rijnstate hospital in Arnhem, Center 2: St. Antonius hospital in Nieuwegeinand Center 3: Haaglanden Medical Center in The Hague,all located in The Netherlands. The national Medical Ethics Review Committee and the local review committee of the individual hospitals approved the protocol of this study. Data were collected retrospectively from medical records and supplemented by data from the standardized lifestyle program that is provided by the (blinded) regarding weight loss, laboratory results, and questionnaires. After data collection at the three individual locations, all data was anonymized.
Prior to any bariatric procedure, patients are extensively screened by a multidisciplinary team to check whether they are eligible for surgery. Before considering a SG, it is especially important for the surgeon to ask for symptoms of GERD and to analyze the pre-operative questionnaire that every patient fills in on GERD symptoms [12]. When patients have complaints of GERD, they are strongly advised to choose for a RYGB instead of a SG. After SG, the decision to choose for SADI-S or RYGB as revisional surgery was made in a shared decision-making approach with the surgeon and patient. If a patient presented with GERD or an anatomical problem after SG, such as a stenosis, a RYGB would be strongly advised. In all other cases, personal preferences of the surgeon and patient led to the decision for either SADI-S or RYGB. The operational techniques and post-operative management have been previously described [11]. From 2014 to 2017, all SADI-S operations were performed with a common channel length of 250cm. However, in 2017 two of the participating centers changed the common channel measurement to 300 cm, leading to four SADI-S patients with a common channel length of 300cm.
Inclusion criteria consisted of age 18–65 years, prior SG surgery, BMI >35kg/m2, and all other criteria described in the European guidelines for bariatric surgery by Fried et al [13]. Patients who experienced complications from the SG could have a BMI <35kg/m2. Exclusion criteria were known unstable malignancies or chemotherapy and less than 3 years of follow-up. For weight loss results, patients who were operated without insufficient weight loss as a main indication for surgery (such as conversion of SG to RYGB because of a functional problem) and pregnant women (from the time of pregnancy until 3 months after parturition) were excluded from the analyses.
Outcome Definition
The primary outcome of interest was weight loss following revisional surgery, defined as percentage total body weight loss (%TWL, weight loss in kilograms at a follow-up time point divided by weight in kilograms measured before revisional surgery). Pre-operative weight was measured on the day of surgery. Follow-up weight was measured at 1.5, 3, 6, 12, 18, and 24 months following revisional surgery and yearly thereafter.
Secondary outcomes were resolution of GERD, complications, micronutrient deficiencies, and quality of life. Resolution of GERD was defined as no medical record of complaints and/or no medication such as proton pomp inhibitors (PPIs) at the last follow-up moment. Medical records were traced from the time of surgery until 5 years of follow-up to search for complications that were related to the bariatric surgical intervention. Laboratory results were collected 6 and 12 months and then yearly after revisional surgery to be analyzed for deficiencies. Patients were included when data on a specific nutrient was available for at least one follow-up moment. The guidelines of the American Society for Metabolic & Bariatric Surgery for the surgical weight loss patient, updated version on micronutrients, were used as a reference for normal and deficient micronutrient lab ranges [14]. When lab ranges for micronutrients were not covered in this guideline, the reference value from the Dutch Association for Clinical Chemistry and Laboratory Medicine was used [15].
QOL was assessed in two out of three centers by using the SF-36 questionnaire on self-rated physical and mental health starting in 2011 [16]. This questionnaire consists of 36 questions and nine scales from which two subtotals could be calculated: physical health summary (PHS) and mental health summary (MHS) score. Besides, health change over the previous year is one out of nine subscales in the questionnaire. A score of 50 is neutral, above 50 is a positive change, and below 50 is a negative change. This questionnaire has been validated for patients with obesity [17].
Statistical Analysis
Retrospectively collected data were analyzed using IBM SPSS version 24 for Windows. Normally distributed values are presented as mean (± standard deviation) and non-normally distributed as median (range). Descriptive statistics were used for demographic variables. Weight loss was only analyzed for patients in which insufficient weight loss was the primary indication for surgery. Differences between groups in weight loss were analyzed by Student’s t test for cross-sectional data and mixed models for longitudinal data. To control for potential confounding, the following variables were added to the longitudinal model: gender, age at revisional surgery, pre-operative weight before revisional surgery, lowest weight after SG and before revisional surgery, and time interval between SG and before revisional surgery. Differences between groups in the occurrence of micronutrient deficiencies and complications were analyzed using the chi-square test. The SF-36 scores for quality of life were analyzed using a Student’s t test for cross-sectional data and mixed models for longitudinal data. A P-value of <0.05 was considered statistically significant.
Results
| SG | SADI-S | RYGB1 | ||||
|---|---|---|---|---|---|---|
| = 141N | ± SD or range | = 63N | ± SD or range | = 78N | ± SD or range | |
| Age (years) | 41.9 | ±11.1 | 43.6 | ±10.6 | 46 | ±11.1 |
| Percentage female | 80.9% | 84.1% | 78.2% | |||
| Weight, kg | 152.6 | ±30.7 | 129.3 | ±21.5 | 112.3 | ±25.5 |
| BMI, kg/m2 | 53.1 | ±9.7 | 44.9 | ±6.2 | 39.1 | ±8.0 |
| Operative time, minutes | 70 | 27–155 | 83.5 | 38–199 | 75.5 | 39 - 212 |
| Hospital stay, days | 1 | 1–8 | 2 | 1–25 | ||
| Years until revision | 3.2 | 1.0–11.9 | 2 | 0.3–6.8 | ||
| Follow-up after revision, years | 4.6 | 3.2–5.6 | 7.8 | 3.2–13.8 | ||
| Comorbidities (%) | ||||||
| Hypertension | 48.4% | 53.9% | ||||
| Diabetes Mellitus | 21.0% | 27.7% | ||||
| Dyslipidemia | 8.1% | 20.5% | ||||
| OSA | 24.2% | 12.9% | ||||
| Physical health summary score2 | 47.7 | 5.0–86.9 | 77.5 | 16.3–96.3 | 60 | 8.9–92.5 |
| Mental health summary score2 | 66.5 | 10.1–94.5 | 73.4 | 28.5–97.8 | 64 | 15.0–93.0 |
Primary Outcome: Weight Loss
To ensure internal validity, the following variables were analyzed as potential confounders for the relationship between %TWL and type of surgery: age at revisional surgery, gender, pre-operative weight before revisional surgery, lowest weight obtained after SG and before revisional surgery, and time interval between SG and revisional surgery. None of these variables was considered to be confounders as they did not change the regression coefficient of %TWL over time in a longitudinal data analysis with more than 10%.
Percentage total weight loss (%TWL) after sleeve gastrectomy and revisional surgery; SG sleeve gastrectomy. Asterisk indicates maximum %TWL obtained after SG and before revisional surgery
| Years post-op | SADI-S* | N | RYGB* | N | -valueP |
|---|---|---|---|---|---|
| 1 | 22.2 ±9.1 | 57 (90%) | 9.7 ±9.5 | 36 (78%) | <.001 |
| 2 | 24.4 ±10.4 | 44 (70%) | 9.0 ±11.5 | 32 (70%) | <.001 |
| 3 | 21.8 ±11.7 | 36 (57%) | 7.2 ±12.5 | 25 (54%) | <.001 |
| 4 | 17.9 ±12.2 | 16 (35%) | 8.2 ±15.1 | 21 (48%) | 0.042 |
| 5 | 15.0 ±22.8 | 9 (47%) | 2.1 ±13.2 | 16 (40%) | 0.057 |
Secondary Outcomes: Quality of Life, Micronutrient Deficiencies, Complications, and Functional Problems
The number of patients who had filled in the quality of life questionnaire both before revisional surgery and at least at one time point post-operatively was 32 (68%) for SADI-S and 28 (47%) for RYGB. In this group of patients, the pre-operative average physical health summary (PHS) score for SADI-S and RYGB was 67.5 and 56.4, respectively. Longitudinal data analyses revealed that SADI-S patients had an average post-operative PHS score over time of 69.0 versus 67.4 for RYGB patients (P=.68). The pre-operative average mental health summary (MHS) score for SADI-S and RYGB was 71.6 and 62.6, respectively. Longitudinal data analyses revealed that the average post-operative MHS score over time was 65.3 for SADI-S and 70.5 for RYGB (P=.183). The self-rated score on health change over the previous year at 1 year post surgery was 81.5 for SADI-S and 80.9 for RYGB patients (P=.88).
Next, a subgroup analysis of RYGB patients who were operated for functional problems versus RYGB patients who were operated for insufficient weight loss was performed. For the functional problems group, the pre-operative PHS and MHS scores were 51.3 and 60.4. The average post-operative scores over time were 62.2 and 67.8, respectively. For the insufficient weight loss group, the pre-operative PHS and MHS scores were 61.0 and 64.6. The average post-operative scores over time were 73.3 and 72.9, respectively. The difference in post-operative PHS and MHS scores between these groups was not statistically significant.
Thirty-nine out of 78 RYGB (50%) patients were operated because of a functional problem related to the SG. Indications for revision were GERD in eleven patients (28%) (in which seven suffered from diaphragmatic herniation), dysphagia in 21 patients (54%) (caused by a stenosis/torsion in nine and concomitant with GERD in one), persistent nausea/vomiting in six patients (15%), and fistula in one patient (3%). When a diaphragmatic hernia was present, it was surgically corrected during RYGB surgery and relieved GERD symptoms after surgery in all patients. At the latest follow-up moment, two out of twelve patients who suffered from GERD still had complaints and one still used a proton pump inhibitor. Revision for nausea/vomiting or a fistula resolved symptoms for all patients. Dysphagia symptoms resolved in nineteen out of 21 cases. One patient still had dysphagia in the years following revision and received enteral tube feeding for several months, while another patient had persistent complaints of abdominal pain in combination with dysphagia and was readmitted to the hospital several times even at 5 years post revisional surgery. For both patients, no anatomical abnormalities related to the RYGB were found that could explain their complaints.
| SADI-S | RYGB | |||||||
|---|---|---|---|---|---|---|---|---|
| Critical range | Pre-op deficient | Post-op deficient | Post-op ()N | Pre-op deficient | Post-op deficient | Post-op ()N | -valueP | |
| Hemoglobin (mmol/l) | M: <8.5F: <7.5a | 7 (11.3%) | 24 (38.7%) | 62 | 12 (17.9%) | 17 (23.9%) | 71 | 0.099 |
| Calcium* (mmol/l) | <2.15b | 2 (5.9%) | 14 (23.3%) | 60 | 2 (6.5%) | 9 (13.0%) | 69 | 0.123 |
| Phosphorus (mmol/l) | <0.9a | 2 (16.7%) | 3 (14.3%) | 21 | 2 (15.4%) | 1 (4.8%) | 21 | 0.29 |
| Iron (μmol/l) | <8.95b | 2 (13.3%) | 9 (30.0%) | 30 | 4 (20.0%) | 6 (17.1%) | 35 | 0.26 |
| Ferritin (μg/l) | <20b | 6 (12.2%) | 16 (27.1%) | 59 | 6 (16.2%) | 22 (33.3%) | 66 | 0.467 |
| Albumin (g/l) | <35a | 0 (0%) | 10 (17.5%) | 57 | 1 (3.9%) | 6 (9.4%) | 64 | 0.197 |
| Total protein (g/l) | <60a | 0 (0%) | 0 (0%) | 21 | 0 (0%) | 0 (0%) | 8 | NA |
| Vitamin A (μmol/l) | <0.7b | 0 (0%) | 0 (0%) | 30 | 0 (0%) | 0 (0%) | 4 | NA |
| Vitamin B1 (nmol/l) | <70b | 0 (0%) | 0 (0%) | 46 | 1 (6.7%) | 0 (0%) | 36 | NA |
| Vitamin B6 (nmol/l) | <35a | 0 (0%) | 0 (0%) | 48 | 0 (0%) | 0 (0%) | 35 | NA |
| Folic acid (nmol/l) | <5a | 1 (2.0%) | 6 (10.3%) | 58 | 2 (5.4%) | 0 (0%) | 66 | 0.008 |
| Vitamin B12 (pmol/l) | <200b | 8 (16.0%) | 2 (3.3%) | 60 | 10 (27.0%) | 20 (30.8%) | 65 | 0 |
| Vitamin D (nmol/l) | <50b | 15 (30.0%) | 15 (24.2%) | 62 | 13 (32.5%) | 19 (27.9%) | 68 | 0.779 |
| Magnesium (mmol/l) | <0.7a | 0 (0%) | 1 (3.5%) | 29 | 0 (0%) | 0 (0%) | 15 | 0.467 |
| Zinc | <9.2b | 0 (0%) | 15 (60.0%) | 25 | 0 (0%) | 1 (16.7%) | 6 | 0.056 |
| Parathyroid hormone | <1.3a | 4 (8.0%) | 1 (1.7%) | 60 | 1 (2.6%) | 1 (1.5%) | 66 | 0.915 |
| SADI-S= 63 (%)N | RYGB= 78 (%)N | Total= 141 (%)N | -valueP | |
|---|---|---|---|---|
| Short-term complications (<30 days) | 5 (7.9%) | 7 (9.0%) | 12 (8.2%) | 0.826 |
| Readmission | 4 | 5 | 9 | |
| Abdominal pain/fever | 2 | 3 | ||
| Deep vein thrombosis | 1 | |||
| Wound infection | 1 | |||
| Persistent nausea | 1 | |||
| Hematemesis | 1 | |||
| Reoperation | 1 | 2 | 3 | |
| Abscess | 1 | |||
| Anastomic leakage | 1 | |||
| Other1 | 1 | |||
| Long-term complications (>30 days–5 years) | 10 (15.9%) | 21 (26.9%) | 31 (22.0%) | 0.115 |
| Readmission | 2 | 3 | 5 | |
| Stenosis2 | 4 | 4 | ||
| Reoperation | 8 | 14 | 22 | |
| Internal herniation | 2 | 7 | ||
| Cicatricial herniation | 1 | 2 | ||
| Revisional surgery | 3 | 1 | ||
| Re-sleeve | 2 | |||
| Anastomic leakage3 | 1 | |||
| Other1 | 4 | |||
| Mortality | 0 | 0 | 0 |
Discussion
To date, there is no consensus on which surgical procedure should be performed after failure of a SG. Therefore, our goal was to compare SADI-S with RYGB following SG on weight loss and quality of life with up to 5 years of follow-up. The present study revealed that SADI-S is more effective in achieving weight loss after a failed SG when compared to RYGB with comparable outcomes in post-operative micronutrient deficiencies, complications, and QOL scores. SADI-S resulted in more than double the amount of weight loss at the latest follow-up following revisional surgery (%TWL after revisional surgery at 1, 2, 3, 4, and 5 years of 22%, 24%, 22%, 18%, and 15% for SADI-S and 10%, 9%, 7%, 8%, and 2% for RYGB). In addition, 78% of patients who received a RYGB never reached an excess weight loss over 50%. However, contrary to our belief after analyzing the results of our previous paper, revisional SADI-S patients do not stay above 20% weight loss on average after 3 years of follow-up.
Few studies have reported on weight loss outcomes of SADI-S as a secondary procedure. Reports on %TWL during the first 2 years after revisional SADI-S surgery vary from 20 to 26% TWL [18–20]. Three studies have demonstrated %TWL results measured from baseline weight at the time of SG and found 38–46% weight loss after SG and SADI-S during 1 to 5 years of follow-up [21–23]. To date, only Sánchez-Pernaute et al (2020) have provided data on weight loss results more than 3 years after SADI-S and reported on the absence of weight regain in this period. Admittedly, this cannot be seen in our data as %TWL drops from more than 20% during the first 3 years to 15% after 5 years. This result may be explained by the fact that only nine patients were included at the 5-year follow-up moment. The poor weight loss results after conversion of a SG to RYGB are in line with those reported in literature. Studies that recommend performing a RYGB after SG for insufficient weight loss usually only report on short-term outcomes [24]. The few long-term reports on %EWL do not often exceed more than 50%, and BMIs under 40kg/m2 are seldomly seen [25]. In our opinion, weight loss results after RYGB are far worse than those after SADI-S. RYGB should therefore not be the recommended procedure after a failed SG due to weight regain or insufficient weight loss.
To the best of our knowledge, quality of life after revisional SADI-S or RYGB surgery has not been studied before. The (blinded) has implemented quality of life follow-up for bariatric patients since 2011. Unfortunately, one out of three centers used a different questionnaire than the SF-36, and some of the patients who received a RYGB fell out of the time frame because they were operated before 2011. This leads to an incomplete dataset, and the results should therefore be interpreted with caution. Surprisingly, the QOL scores at baseline were lower for the RYGB group, even when dividing this group into patients with functional problems versus patients with insufficient weight loss. It is possible that patients with higher QOL and weight at baseline were more likely to make the decision for SADI-S which can be seen as a more invasive procedure than RYGB. Both for SADI-S and RYGB, a positive change in health score of 81 and 82, respectively, was found 1 year after surgery (50 is neutral). Longitudinal data analysis of change in mental and physical health score following revisional surgery showed no significant difference between SADI-S and RYGB. It might be speculated that a trend towards better QOL scores is seen after RYGB; however, the groups are too small to draw conclusions from. This trend cannot be explained by inclusion of patients who were operated because of a functional problem with the SG in the RYGB group since a subgroup analysis showed the same improvement in QOL for those operated for insufficient weight loss. We hypothesized that QOL would be better after SADI-S if weight loss is greater with a similar rate of deficiencies and complications. Unfortunately, this cannot be seen in our data.
A concern from procedures with possible significant malabsorptive properties such as SADI-S is the risk of micronutrient and even macronutrient deficiencies. Apparent from our data for both SADI-S and RYGB is the occurrence of a ferritin deficiency and anemia after surgery in about 25–40%, a vitamin D deficiency in 25%, and up to 18% of patients developing an albumin deficiency. Vitamin B12 was significantly more often deficient after RYGB, whereas SADI-S patients developed more folic acid deficiencies. Factors underlying a vitamin B12 deficiency after conversion of SG to RYGB are probably diminished contact of food with gastric acid and decreased secretion of intrinsic factor, unlike after SADI-S where the gastric antrum is preserved [26–28].
The main reason for introducing the SADI-S was to find a better alternative than the original BPD-DS in terms of operative risk and complications. In the present study, no statistical difference was found in overall complication rates after SADI-S or RYGB, as was expected after our previous paper. Internal herniation was found more often after RYGB, as was expected as a RYGB has two potential herniation sites. This is an important outcome, while although the difference is not statistically significant, it is probably due to a type two error and would become significant when more patients would have been available. During the first 5 years after revision, the combined risk for a complication related to the bariatric procedure was 30% of which 58% required surgery. Prior studies have noted that complication rates are generally reported to be higher after revisional surgery compared to primary procedures [29–31]. However, papers do not typically report on re-operation and long-term complication rates, especially after revisional surgery which makes it hard to compare these results. Nonetheless, our data supports the hypothesis that complications are not more common after revisional SADI-S than after RYGB surgery.
Failure of the SG because of a functional problem such as GERD, dysphagia, persistent nausea and vomiting, or a fistula occurred in 39 out of 141 patients (28%). GERD can be seen after a complex interaction of problems including the prevalence of hiatus hernia, increased intra-abdominal pressure, and a malfunctioning lower esophageal sphincter causing decreased gastric emptying which all can be caused by obesity alone [32]. The high-pressure environment created by a SG can cause GERD symptoms to worsen or de novo GERD to occur. A recent study by Mandeville et al. (2017) showed that in one hundred patients, the chance of developing de novo GERD after a SG was up to 48% [33]. By performing a RYGB after a SG, the pylorus is bypassed promoting gastric emptying and relieving pressure which in theory should resolve most of the GERD symptoms, as has also been supported by literature [8, 34–36]. This is also shown in our results as out of 39 patients who were operated because of a functional problem, all but two were free of GERD symptoms. The fact that two patients still had complaints of GERD addresses the complexity of the problem. Converting SG to SADI-S in patients that do not have GERD complaints does not provoke GERD symptoms as the anatomy of the stomach is left untouched during this procedure.
Finally, a number of potential limitations must be considered. As with any retrospective study, there is a risk that missed appointments and insufficient data would be available to answer a research question. Another limitation is the small sample size of SADI-S patients who have reached 5 years of follow-up and the low percentage of data available at this time point. Also, data on QOL was not available for all participating centers and was missing for RYGB patients who were operated before 2011. Accordingly, data that was available for analysis with percentages was given for every outcome to optimize transparency.
Future research should focus on long-term follow-up and emphasize on the role of quality of life. What factors impact quality of life after revisional surgery is a topic that was beyond the scope of the current study but is an important question for future studies. Unfortunately, because of the small sample size that comes along with a very specific group of patients requiring revisional surgery after a SG and their non-compliance to follow-up leading to missing data, it is not possible to draw hard clinical recommendations out of one study. Nonetheless, we can still state that this is the largest scientific comparison of revisional SADI-S and RYGB after SG and it provides a framework for future research on quality of life.
Conclusion
Converting a SG to SADI-S results in significantly more weight loss than conversion to RYGB up to 4 years post-revision. The average quality of life scores over time did not differ between SADI-S and RYGB, and the rate/percentage of complications and micronutrient deficiencies was similar. Therefore, conversion from a SG into a RYGB is not the preferred procedure unless GERD or functional problems related to the SG are the primary indication for revisional surgery.