Purifying peptides from the whiteleg shrimp that block egg yolk formation

Seven peptides from the crustacean hyperglycemic hormone family were identified in the whiteleg shrimp, with Liv-SGP-G exhibiting the strongest vitellogenesis-inhibiting activity.

• The study characterized multiple vitellogenesis-inhibiting hormones (VIH) in the whiteleg shrimp.
• Six of the seven identified peptides significantly reduced vitellogenin mRNA levels, with varying efficacy.
• Liv-SGP-G was the most abundant peptide and showed strong inhibition of vitellogenesis.
• Liv-SGP-D did not demonstrate significant inhibitory activity on vitellogenin mRNA levels.
• The complete primary structure of Liv-SGP-G consists of 72 amino acid residues with an amidated C-terminus.

Simplified