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Abstract
A multifunctional lipid nanoparticle engineered with SitoC7A significantly enhances mRNA vaccine efficacy.
- The SitoC7A component improves uptake of lipid nanoparticles by dendritic cells, leading to increased mRNA translation.
- Selective activation of STING signaling in dendritic cells avoids systemic interferon responses that could hinder vaccine effectiveness.
- In murine models, SitoC7A-LNPs containing SARS-CoV-2 mRNA produced strong protective immunity.
- Tumor antigen-loaded lipid nanoparticles demonstrated a significant reduction in lymphoma progression.
- This lipid nanoparticle design integrates structural support, enhanced mRNA delivery, and controlled immune activation for improved vaccine performance.
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