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Modulation of lipid nanoparticle-formulated plasmid DNA drives innate immune activation promoting adaptive immunity
Changes in lipid nanoparticle DNA trigger immune response that supports long-term immunity
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Abstract
HA DNA-LNP induced superior antigen-specific CD8T cell responses that persisted beyond one year.
- The DNA-LNP formulation elicited robust innate and adaptive immunity, showing similar serological potency to mRNA-LNPs and adjuvanted protein.
- Priming with HA DNA-LNP resulted in STING-dependent activation of migratory dendritic cell subpopulations.
- In rabbits, immune responses from HA DNA-LNP were comparable or superior to those induced by mRNA-LNPs at the same dose.
- A SARS-CoV-2 spike-encoding DNA-LNP demonstrated protective efficacy similar to that of spike mRNA-LNPs.
- The findings suggest a distinct priming mechanism for DNA-LNPs that differs from mRNA-LNPs and adjuvanted protein.
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