Sleep abnormalities in bipolar disorders across mood phases: A systematic review and meta-analysis

Jul 24, 2025Sleep medicine reviews

Sleep problems in bipolar disorder during different mood phases: A review and combined analysis

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Abstract

Poor sleep quality prevalence in bipolar disorder is 52% during euthymia and 63% during the depressive phase.

  • Individuals with euthymic bipolar disorder reported worse sleep quality and had longer total sleep time and sleep onset latency compared to controls.
  • Higher percentages of rapid eye movement sleep were observed in the depressive phase of bipolar disorder.
  • The manic/mixed phase exhibited shorter total sleep time, lower sleep efficiency, and longer sleep onset latency.
  • Bipolar disorder showed greater variability in sleep duration and continuity during euthymia.
  • Prominent differences in sleep measures were noted between sleep diary reports and objective assessments.

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