Multicenter Study on Sleep and Circadian Alterations as Objective Markers of Mild Cognitive Impairment and Alzheimer’s Disease Reveals Sex Differences

Nov 13, 2020Journal of Alzheimer's disease : JAD

Sleep and body clock changes linked to mild memory problems and Alzheimer's disease show differences between men and women

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Abstract

Wake after sleep onset (WASO) was significantly higher in mild cognitive impairment (MCI) patients compared to controls (p < 0.001).

Sleep efficiency (SE) was lower in MCI patients (p = 0.003) and in male Alzheimer's disease (AD) patients compared to female AD patients (p = 0.038).
The Sleep Regularity Index (SRI) was lower in AD patients compared to controls (p = 0.004) and in male AD patients compared to male controls (p = 0.008) and female AD patients (p = 0.046).
Mesor values were significantly lower in males across the overall population.
Age influenced differences in WASO and SE, while sex differences were noted in amplitude (p = 0.009) for the overall population and controls.
Actigraphic data showed good predictive power for identifying disease or health status.

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BACKGROUND: Circadian and sleep disturbances are associated with increased risk of mild cognitive impairment (MCI) and Alzheimer's disease (AD). Wearable activity trackers could provide a new approach in diagnosis and prevention.

OBJECTIVE: To evaluate sleep and circadian rhythm parameters, through wearable activity trackers, in MCI and AD patients as compared to controls, focusing on sex dissimilarities.

METHODS: Based on minute level data from consumer wearable devices, we analyzed actigraphic sleep parameters by applying an electromedical type I registered algorithm, and the corresponding circadian variables in 158 subjects: 86 females and 72 males (42 AD, 28 MCI, and 88 controls). Moreover, we used a confusion-matrix chart method to assess accuracy, precision, sensitivity, and specificity of two decision-tree models based on actigraphic data in predicting disease or health status.

RESULTS: Wake after sleep onset (WASO) was higher (p < 0.001) and sleep efficiency (SE) lower (p = 0.003) in MCI, and Sleep Regularity Index (SRI) was lower in AD patients compared to controls (p = 0.004). SE was lower in male AD compared to female AD (p = 0.038) and SRI lower in male AD compared to male controls (p = 0.008), male MCI (p = 0.047), but also female AD subjects (p = 0.046). Mesor was significantly lower in males in the overall population. Age reduced the dissimilarities for WASO and SE but demonstrated sex differences for amplitude (p = 0.009) in the overall population, controls (p = 0.005), and AD subjects (p = 0.034). The confusion-matrices showed good predictive power of actigraphic data.

CONCLUSION: Actigraphic data could help identify disease or health status. Sex (possibly gender) differences could impact on neurodegeneration and disease trajectory with potential clinical applications.

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Multicenter Study on Sleep and Circadian Alterations as Objective Markers of Mild Cognitive Impairment and Alzheimer’s Disease Reveals Sex Differences

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