Inflammatory bowel diseasesNov 3, 2018

The Two-Way Relationship Between Sleep and Inflammatory Bowel Disease

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated Apr 5, 2026

Abstract

Poor sleep is associated with increased disease activity in inflammatory bowel disease (IBD).

Sleep deprivation may influence inflammation and immune responses.
Poor sleep has been linked to subclinical inflammation in IBD patients.
Sleep disturbances could predict relapse and poorer outcomes in IBD.
The review discusses causes of poor sleep in individuals with IBD.
Potential therapeutic interventions for managing sleep disturbances are suggested.

Simplified

Sleep deprivation and lack of sleep are a significant public health concern. Several studies have suggested an intricate relationship between sleep, inflammation, and the immune system. Poor sleep has been described well in subjects with inflammatory bowel disease (IBD) and has been linked to disease activity and shown as a predictor for subclinical inflammation and a risk factor for relapse and poorer outcomes. This review describes the relationship between poor sleep, inflammation, and the immune system. Furthermore, the relationship between sleep and IBD are reviewed. The causes of poor sleep in inflammatory bowel disease patient is discussed. Potential therapeutic interventions for the management of common sleep disturbances are provided.

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The Two-Way Relationship Between Sleep and Inflammatory Bowel Disease

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