Chronobiology international

Sleep quality linked to DNA changes in tumor-suppressing genes in nurses and midwives

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Abstract

A borderline significant association was observed between shorter sleep duration and increased methylation levels in CDKN2A among day working nurses and midwives.

  • Chronic sleep restriction may impact metabolism, hormone secretion, and inflammation.
  • Limited evidence suggests it could also lead to epigenetic changes, including alterations in DNA methylation.
  • The study assessed the relationship between sleep quality, duration, and methylation of tumor suppressor genes in a sample of 710 nurses and midwives aged 40-60.
  • No significant differences were found in the overall population or in subgroups based on work systems.
  • Findings indicate a potential link that merits further investigation.

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