Association of sleep traits with benign prostatic hyperplasia in middle‐aged and elderly men: A prospective analysis in UK Biobank

May 20, 2024Geriatrics & gerontology international

Link between sleep patterns and non-cancer prostate enlargement in middle-aged and older men

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Abstract

During a median follow-up of 12.0 years, 13,026 incident cases of benign prostatic hyperplasia (BPH) were recorded among 170,241 men.

Sleep duration of 7-8 hours per day is associated with a reduced risk of BPH (hazard ratio 0.95).
No frequent insomnia is linked to a lower BPH risk (hazard ratio 0.71).
No frequent daytime sleepiness is connected with reduced BPH risk (hazard ratio 0.86).
A one-point increase in a healthy sleep score is associated with a decreased risk of BPH (hazard ratio 0.90).
Men with five low-risk sleep traits have a significantly lower risk of BPH compared to those with zero to one low-risk trait (hazard ratio 0.68).
Approximately 9.1% of BPH cases could potentially be prevented by adopting all five low-risk sleep traits.

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AIMS: The association of sleep traits (insomnia, sleep duration, chronotype, daytime sleepiness, and snoring) with benign prostatic hyperplasia (BPH) is unclear. This research aimed to examine the effects of sleep traits on BPH risk.

METHODS: A total of 170 241 men aged 38 to 73 years from UK Biobank were included. An overall healthy sleep score was created based on five sleep traits. A Cox regression model was utilized to compute adjusted hazard ratios (HRs) and population attributable fractions (PAFs) with 95% confidence intervals (CIs) for BPH risk in relation to sleep traits.

RESULTS: During a median of 12.0 years follow-up, 13 026 incident BPH cases occurred. We observed that sleep duration (7-8 h/d; HR 0.95; 95% CI 0.92-0.99), no frequent insomnia (HR 0.71; 95% CI 0.69-0.74), and no frequent daytime sleepiness (HR 0.86; 95% CI 0.79-0.93) were significantly related to reduced BPH risk. Each one-point increment of the healthy sleep score was related to a decreased BPH risk, with an adjusted HR of 0.90 (95% CI 0.89-0.92). The multivariable-adjusted HR in men adopting five versus zero to one low-risk sleep traits was 0.68 (95% CI 0.61-0.75) for BPH risk. Estimates of the PAF indicated that 9.1% (95% CI 5.8-12.5%) of BPH cases would be prevented if all individuals had adopted all five low-risk sleep traits, assuming causality.

CONCLUSIONS: Our study indicates an association between a healthy sleep pattern and a lower risk of BPH, emphasizing the importance of adhering to such patterns for potentially reducing BPH risk. Geriatr Gerontol Int 2024; 24: 675-682.

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Association of sleep traits with benign prostatic hyperplasia in middle‐aged and elderly men: A prospective analysis in UK Biobank

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