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Small-Molecule Modulation of the Circadian Clock in Cancer and Aging
How Small Molecules May Influence the Body’s Internal Clock in Cancer and Aging
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Abstract
Circadian rhythms, which are ~24 h cycles, play a significant role in health and disease.
- Disruption of circadian rhythms may contribute to the progression of cancers and aging-related declines in function.
- Small molecules identified can modulate core circadian clock proteins and pathways, presenting potential therapeutic strategies.
- Clock-modulating compounds have been shown to impact tumor metabolism, cell growth, and effectiveness of cancer treatments.
- Strengthening circadian function in aging models may improve metabolic health and potentially increase longevity.
- Challenges include managing off-target effects and understanding the complex regulation of circadian clocks.
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