Journal of diabetes investigation

Trends in prescribing diabetes drugs that lower blood sugar and protect heart and kidney health in South Korea from 2015 to 2021

Updated

Abstract

SGLT2 inhibitor prescriptions increased from 2.5% in 2015 to 13.9% in 2021.

  • The overall number of individuals prescribed oral glucose-lowering drugs rose from 2015 to 2021.
  • There was a 9.2 percentage point decrease in individuals receiving monotherapy or dual combination therapy.
  • The proportion of individuals receiving triple or more combination therapy increased during the same period.
  • Individuals with heart failure experienced a significant rise in SGLT2i prescriptions, from 2.2% in 2015 to 16.6% in 2021.
  • The mean time to SGLT2i initiation after diagnosis decreased from 249 days in 2015 to 158 days in 2019.
  • Despite increased adoption, the overall use of SGLT2i among individuals with cardiovascular-renal disease remained limited.

Simplified

Key numbers

11.4 percentage points
Increase in SGLT2i Prescription Rate
Proportion of individuals prescribed SGLT2is rose from 2.5% in 2015 to 13.9% in 2021.
91 days
Decrease in Time to SGLT2i Initiation
Mean time to SGLT2i initiation decreased from 249 days in 2015 to 158 days in 2019.
1,411,766
Increase in Individuals Prescribed Oral Glucose-Lowering Drugs
Number of individuals prescribed oral glucose-lowering drugs increased from 1,847,901 in 2015 to 3,259,667 in 2021.

Full Text

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Funding

Competing interests

K.H.H. has no relevant disclosures. S.S. and E.N. are employees of Boehringer Ingelheim. D.J.K. has received grants or research support from Boehringer Ingelheim, LG Chem, and Novo Nordisk. D.J.K. is an Editorial Board member of the Journal of Diabetes Investigation and a co‐author of this article. To minimize bias, he was excluded from all editorial decision‐making related to the acceptance of this article for publication. The authors meet the criteria for authorship as recommended by the International Committee of Medical Journal Editors (ICMJE). The authors did not receive payment related to the development of the article. Boehringer‐Ingelheim was given the opportunity to review the manuscript for medical and scientific accuracy as well as intellectual property considerations. Approval of the research protocol: The study protocol was approved by the Institutional Review Board of Ajou University Hospital, Suwon, Republic of Korea (approval no. AJOUIRB‐EXP‐2022‐355). Informed consent: Because this was a retrospective study, the requirement for informed consent was waived. Approval date of registry and the registration no. of the study/trial: N/A. Animal studies: N/A.
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