[The effect of steroid hormone on oxytocin receptor expression in primary human uterine myometrial cell culture].

Estradiol increased oxytocin receptor binding values to 36.20 pM/mg protein at 72 hours in cultured human myometrial cells.

• Oxytocin receptor binding values increased in the presence of estradiol at concentrations of 10(-8) M and 10(-7) M over 72 hours.
• Dehydroepiandrosterone sulfate at 10(-5) M showed almost no effect on oxytocin receptor expression when combined with estradiol.
• Cortisol at 10(-5) M decreased oxytocin receptor expression induced by estradiol.
• Progesterone inhibited the increase in oxytocin receptor expression caused by estradiol in a concentration-dependent manner.
• The concentration of progesterone that reduced oxytocin receptor binding by 50% was 2.7 x 10(-6) M.

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