Strength exercise reduces hepatic pyruvate carboxylase and gluconeogenesis in DIO mice

Obese animals had an increased hepatic pyruvate carboxylase (PC) level, which was reduced following 15 days of short-term strength training.

• Obesity is associated with higher levels of hepatic pyruvate carboxylase, a key enzyme in glucose production.
• Short-term strength training significantly reduced hyperglycemia and insulin resistance in obese mice.
• The metabolic benefits of strength training may relate to improved control of hepatic glucose production and increased insulin sensitivity.
• Hepatic PC mRNA levels positively correlate with glucose levels and adiposity while negatively correlating with locomotor activity and muscle mass.
• The findings suggest that short-term strength training can effectively decrease the hepatic PC content in obese animals.

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